منابع مشابه
RNAi-mediated DNA silencing
Tucker, and Edwin Chapman (University of Wisconsin, Madison, WI) find that PIP 2 is a plasma membrane dock for synaptotagmin-1 (syt), a transmembrane protein localized in secretory vesicle membranes, when calcium is absent. This dock may ensure speedy and directed fusion in response to calcium influx. The syt dock has two calcium-binding domains in its cytoplasmic region, called C 2 A and C 2 B...
متن کاملRNAi libraries and kinetoplast DNA.
African trypanosomes have a remarkable mitochondrial DNA termed kDNA (kinetoplast DNA) that contains several thousands of topologically interlocked DNA rings. Because of its highly unusual structure, kDNA has a complex replication mechanism. Our approach to understanding this mechanism is to identify the proteins involved and to characterize their function. So far approx. 30 candidate proteins ...
متن کاملSynthetic Biology Takes on Zika.
By the time public health officials implement infrastructure to deal with an outbreak, the threat has often passed. This could change with innovation on a new diagnostic work flow and platform designed by Jim Collins, a professor at the Massachusetts Institute of Technology (MIT). Many innovators develop a novel assay and stop there. When Collins, a design thinker, explores a new novel assay, h...
متن کاملNY DEC Takes on Fracking
assessment, human health, environmental fate and impact, risk assessment and risk management, and informatics and modeling. The emphasis on informatics and modeling, new for this update of the strategy, reflects the need for a way to organize the rapidly growing wealth of data on ENMs. Coral reefs sequester carbon dioxide, support fisheries, protect the coastline from storms, and help generate ...
متن کاملTOPBP1 takes RADical command in recombinational DNA repair
TOPBP1 is a key player in DNA replication and DNA damage signaling. In this issue, Moudry et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201507042) uncover a crucial role for TOPBP1 in DNA repair by revealing its requirement for RAD51 loading during repair of double strand breaks by homologous recombination.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2002
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1586rr4